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CFTR corrector 4

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Purity:98.43%

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COA FNMR HPLC HNMR ORP

CFTR corrector 4

Catalog No. T10776Cas No. 1918142-34-3

CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface and is a potential compound for the study of cystic fibrosis.

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Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$178	In Stock
10 mg	$278	In Stock
25 mg	$563	In Stock
50 mg	$793	In Stock
100 mg	$1,130	In Stock
500 mg	$2,260	In Stock
1 mL x 10 mM (in DMSO)	$213	In Stock

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Product Introduction

Bioactivity

Description	CFTR corrector 4 is a potent and orally available transmembrane conductance regulator (CFTR) for cystic fibrosis and is a potent (R,R) type active enantiomer. CFTR corrector 4 increases CFTR levels on the cell surface and is a potential compound for the study of cystic fibrosis.
In vitro	CFTR corrector 4 (Compound 13) possesses high potency and efficacy with an EC50 of 0.028 μM in HBE-TECC assay that assesses the CFTR function. CFTR corrector 4 is tested its potency and efficacy in human bronchial epithelial (HBE) cells with an EC50 value of 130 nM in the cell surface expression (CSE-HRP) assay.[1]

Chemical Properties

Molecular Weight	539.52
Formula	C29H27F2NO7
Cas No.	1918142-34-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (92.67 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8535 mL	9.2675 mL	18.5350 mL	92.6750 mL
5 mM	0.3707 mL	1.8535 mL	3.7070 mL	18.5350 mL
10 mM	0.1853 mL	0.9267 mL	1.8535 mL	9.2675 mL
20 mM	0.0927 mL	0.4634 mL	0.9267 mL	4.6337 mL
50 mM	0.0371 mL	0.1853 mL	0.3707 mL	1.8535 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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